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NPC Rapid Review Fenofibrate does not reduce CV events in patients with type 2 diabetes when added to simvastatin Rapid reviews | Podcasts | Shared practice examples | Events | Publications and resources | FAQs | Email alerts | Newsroom | Contact us | A to Z The ACCORD lipid trial in patients with type 2 diabetes concluded that intensifying lipid modification therapy through combination use of fenofibrate and simvastatin (at a daily dose of 40mg or less) did not reduce the rate of fatal CV events, non-fatal myocardial infarction or stroke, as compared with simvastatin alone.NICE guidance on the management of type 2 diabetes recommends that if the cardiovascular (CV) risk is high (as is usual in people with type 2 diabetes) consider adding a fibrate to statin therapy if triglyceride levels remain in the range 2.3 to 4.5mmol/litre despite statin therapy. Health professionals should continue to follow NICE guidance with respect to management of lipid levels in diabetes, but may wish to consider the implications of additional information now available from the ACCORD lipid study when discussing with patients the risks and benefits of adding a fibrate to statin therapy.Review: The role of fenofibrate in reducing cardiovascular risk in type 2 diabetes Sign In Dyslipidaemia (elevated triglycerides, low high-density lipoprotein-cholesterol [HDL-C] and an increase in small, dense low-density lipoprotein [LDL] particles) is an important contributor to the increased cardiovascular risk associated with type 2 diabetes. Lowering LDL-C levels with a statin is the main focus of lipid-modifying intervention. Fibrates are effective against all components of this atherogenic mixed dyslipidaemia. Adding a fibrate to primary statin therapy is a logical approach to achieving all lipid targets. Evidence from the Fenofibrate Invention and Event Lowering in Diabetes trial also shows that fenofibrate is a well-tolerated option with potential benefits on the progression of microvascular complications of type 2 diabetes. Thus fenofibrate-statin combination therapy may translate into greater reductions in vascular risk.fenofibrate, safety, type 2 diabetes. Reviews and User Ratings: Effectiveness, Ease of Use, and SatisfactionYou are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Some of these opinions may contain information about treatment or uses of drug products that have not been approved by the U.S. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment.Fenofibrate Drug Review � Fenofibrate Side Effects and Dosage | Drugs Mega | Drugs ReviewFenofibrate is a cholesterol controlling drug that comes under fibrate class.� It is generally recommended to patients at the risk of cardiovascular disease. It is also found that Fenofibrate is helpful in insulin resistance during muscular syndrome. Controlling the blood fat is also an added advantage of this drug.
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